Locksie grew up in the church—against her will—thanks to her holier than thou mother. But now that she's all grown up, she's her own woman, and church is the last thing on her mind. Her live-in boyfriend, Dawson, is the first. Locksie has shared a wonderful three years with Dawson without half the drama that she hears about from the clients in the salon she manages. But lately, Locksie is beginning to feel as though something is missing from her near perfect romance. When she goes to her favorite aunt, Mary, for some guidance, she doesn't like the direction her aunt is trying to steer her in. Locksie quickly realizes, though, that she can run from her problems, but she can't hide from the truth.
Hannah is one of Locksie's faithful clients who tries to offer her some advice, but Hannah's got issues of her own. She's struggling to forgive her husband for cheating, all while being a stepmother to the child who was a result of his affair. The child's mother taunts Hannah every chance she gets.
In Me, Myself and Him, these women are torn between holding on to the men they love, or having to let go for the one thing that's missing from their lives.