Jax Sequeros is the sole-surviving member of an ancient cult of vampire killers, the Sangue Cacadore. He promised his father he would carry on the traditions of the group—a unique band of shape-shifters who change into black panthers—and breed a new generation.

Jax has no problem with carrying out his father's wishes, until he meets Michel Chopiak, a Russian sex-slave. With the aid of a gay elf named Al Fairfeather, his friend Corey—who is a vampire—and a fairy named Lorelai, Jax takes up his heritage and goes on a vampire hunt, but what he finds is the love of his life.